Synaptic Plasticity presents an up-to-date overview of the current status of research on the full scope of synaptic plasticity, including synaptic remodeling in response to damage, long-term depression and long-term potentiation, and learning and memory.The contributions are written by leading experts in the field and cover approaches from biochemical, anatomical, physiological, behavioral, and computational levels. They offer hypotheses concerning the molecular and cellular mechanisms that are responsible for the various manifestations of synaptic plasticity and propose models explaining how these cellular events can be linked to the functional and behavioral expressions of these adaptive principles.Michel Baudry is Associate Professor in the Department of Biological Sciences at the University of Southern California. Richard F. Thompson is Director of the Neuroscience Program and Keck Professor of Psychology and Biological Sciences at the University of Southern California. Joel L. Davis is Scientific Officer for Computational Neuroscience at the Office of Naval Research.Contents: Introduction. Molecular Correlates of Activity-dependent Development and Synaptic Plasticity, S. Hockfield. Molecular Sorting in Neurons, 0. Steward. Molecular and Morphological Responses to Deafferentation in Rodents, C. E. Finch, T. H. McNeill. Forms of Long-term Potentiation Induced by NMDA and Non–NMDA Receptor Activation, T. Teyler, L. Grover. Long-term Potentiation: Biochemical Mechanisms, M. Baudry, G. Lynch. Cerebellar Mechanisms of Long-Term Depression, M. Ito. Long-term Depression: Related Mechanisms in Cerebellum, Neocortex, and Hippocampus, A. Artola, W. Singer. Theory of Synaptic Plasticity in Visual Cortex, N. Intrator, M. F. Bear, L. N. Cooper, M. A. Paradiso. A Theoretical and Experimental Strategy for Realizing a Biologically Based Model of the Hippocampus, T. W. Berger et al. Synaptic Plasticity, Learning, and Memory, S. P. Rose. Synaptic Plasticity and Memory Storage, R. F. Thompson et al.
Many neurons exhibit plasticity; that is, they can change structurally or functionally, often in a lasting way. Plasticity is evident in such diverse phenomena as learning and memory, brain development, drug tolerance, sprouting of axon terminals after a brain lesion, and various cellular forms of activity-dependent synaptic plasticity such as long-term potentiation and long-term depression. This book, a follow-up to the editors' Synaptic Plasticity (MIT Press, 1993), reports on the most recent trends in the field. The levels of analysis range from molecular to cellular and network, the unifying theme being the nature of the relationships between synaptic plasticity and information processing and storage.
Contributors: Yael Amitai, Michel Baudry, Theodore W. Berger, Pierre-Alain Buchs, A. K. Butler, Franck A. Chaillan, Gilbert A. Chauvet, Marie-Françoise Chesselet, Barry W. Connors, Taraneh Ghaffari, Jay R. Gibson, Ziv Gil, Michel Khrestchatisky, Dietmar Kuhl, Carole E. Landisman, Gilles Laurent, Jim-Shih Liaw, David J. Linden, Katrina MacLeod, Henry Markram, W. V. Morehouse, Dominique Muller, J. A. Napieralski, Santiago Rivera, François S. Roman, Bernard Soumireu-Mourat, Oswald Steward, Mark Stopfer, F. G. Szele, Richard F. Thompson, Nicolas Toni, Bernard Truchet, Misha Tsodyks, K. Uryu, Ascher Uziel, Christopher S. Wallace, Yun Wang, Michael Wehr, Paul F. Worley, Xiaping Xie.
This is the third volume in a series of books devoted to the mechanisms and functional significance of two forms of synaptic plasticity, Long-Term Potentiation (LTP) and Long-Term Depression (LTD), which are widely assumed to play critical roles in information processing and storage in the brain. Long-Term Potentiation offers the most recent hypotheses concerning the molecular and cellular mechanisms underlying LTP and LTD, discusses the functional significance of LTP and LTD in neuronal networks, and reviews several examples of network simulations incorporating LTP- and LTD-like rules of synaptic modification.
The book is organized into several sections covering different aspects of the field ranging from molecular and cellular processes to network models. The often deliberately controversial contributions are from the leading laboratories in the field and reflect contemporary multidisciplinary approaches.