Modern machine learning techniques are proving to be extremely valuable for the analysis of data in computational biology problems. One branch of machine learning, kernel methods, lends itself particularly well to the difficult aspects of biological data, which include high dimensionality (as in microarray measurements), representation as discrete and structured data (as in DNA or amino acid sequences), and the need to combine heterogeneous sources of information. This book provides a detailed overview of current research in kernel methods and their applications to computational biology.
Following three introductory chapters—an introduction to molecular and computational biology, a short review of kernel methods that focuses on intuitive concepts rather than technical details, and a detailed survey of recent applications of kernel methods in computational biology—the book is divided into three sections that reflect three general trends in current research. The first part presents different ideas for the design of kernel functions specifically adapted to various biological data; the second part covers different approaches to learning from heterogeneous data; and the third part offers examples of successful applications of support vector machine methods.
About the Editors
Bernhard Schölkopf is Professor and Director at the Max Planck Institute for Biological Cybernetics in Tübingen, Germany. He is coauthor of Learning with Kernels (2002) and is a coeditor of Advances in Kernel Methods: Support Vector Learning (1998), Advances in Large-Margin Classifiers (2000), and Kernel Methods in Computational Biology (2004), all published by the MIT Press.
Koji Tsuda is a Research Scientist at the Max Planck Institute and a Researcher at AIST Computational Biology Research Center, Tokyo.
Jean-Philippe Vert is Researcher and Leader of the Bioinformatics Group at École des Mines de Paris.
"This timely collection will be an asset to anyone working with microarray data, and those involved with computational biology more generally should be aware of it."
—Jun Liu, Professor of Statistics, Harvard University
"This unique collection admirably covers the topic of using kernel methods to study biological data, providing up-to-date treatment of work in the field."
—Junhyong Kim, Department of Biology, University of Pennsylvania