| Preface
 Sample Chapter - Download PDF (98 KB) | xi |
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| 1 | In the Beginning ...
Sample Chapter - Download PDF (22.20 MB) | 1 |
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| | 1.1 | Approaching the Study of Life | 1 |
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| | 1.2 | Billions and Billions of Creatures ... | 5 |
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| | 1.3 | ... All Alike | 11 |
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| | 1.4 | Where To from Here | 16 |
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| 2 | Evolution | 19 |
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| | 2.1 | Inheritance | 23 |
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| | 2.2 | Variation | 28 |
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| | 2.3 | Selection | 34 |
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| | 2.4 | A Brief History of Life on Earth | 41 |
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| | 2.5 | Evolution and Life | 47 |
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| | 2.6 | Suggested Readings | 47 |
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| 3 | A Little Bit of Chemistry | 49 |
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| | 3.1 | Matter | 49 |
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| | | 3.1.1 | Atoms | 50 |
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| | | 3.1.2 | Molecules and Bonds | 54 |
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| | 3.2 | Reactions | 58 |
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| | 3.3 | Organic Chemistry | 62 |
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| | 3.4 | Energy and Thermodynamics | 66 |
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| | 3.5 | Chemistry and Life | 70 |
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| | 3.6 | Suggested Readings | 71 |
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| 4 | The Structure and Function of Bacteria | 73 |
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| | 4.1 | Membranes and Boundaries | 75 |
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| | 4.2 | Cytoplasm and Metabolism | 77 |
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| | 4.3 | Chromosomes and Genomes | 82 |
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| | 4.4 | Bacterial Life | 86 |
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| | 4.5 | Suggested Readings | 88 |
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| 5 | Biological Macromolecules | 91 |
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| | 5.1 | Protein | 92 |
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| | | 5.1.1 | Protein Structure | 95 |
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| | | 5.1.2 | Protein Evolution | 102 |
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| | | 5.1.3 | Protein Function | 103 |
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| | 5.2 | Nucleic Acids | 104 |
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| | | 5.2.1 | DNA | 104 |
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| | | 5.2.2 | RNA | 107 |
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| | | 5.2.3 | DNA Evolution | 111 |
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| | 5.3 | Macromolecules and Life | 116 |
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| | 5.4 | Suggested Readings | 117 |
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| 6 | Eukaryotes | 119 |
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| | 6.1 | Eukaryotic Gene Structure and Transcription | 120 |
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| | 6.2 | Components of the Eukaryotic Cell | 124 |
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| | | 6.2.1 | The Nucleus | 124 |
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| | | 6.2.2 | The Endoplasmic Reticulum and Golgi Apparatus | 126 |
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| | | 6.2.3 | The Mitochondrion | 126 |
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| | | 6.2.4 | The Chloroplast | 130 |
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| | | 6.2.5 | Other Plastids | 133 |
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| | | 6.2.6 | The Proteasome, the Lysosome, and the Peroxisome | 133 |
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| | 6.3 | Lifestyles of the Single-Celled Eukaryote | 134 |
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| | 6.4 | Suggested Readings | 137 |
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| 7 | Multicellular Organisms and Development | 139 |
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| | 7.1 | The Origin of Multicellular Organisms | 139 |
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| | 7.2 | Development | 145 |
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| | | 7.2.1 | Molecular Maps | 148 |
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| | | 7.2.2 | Cell-to-Cell Signaling | 151 |
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| | | 7.2.3 | Cell Motion | 153 |
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| | | 7.2.4 | Differentiation | 156 |
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| | | 7.2.5 | Organogenesis | 158 |
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| | 7.3 | Growth | 159 |
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| | 7.4 | Multicellular Life and Humanity | 162 |
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| | 7.5 | Suggested Readings | 163 |
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| 8 | Anatomy, Physiology, and Systems Biology | 165 |
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| | 8.1 | Homeostasis | 165 |
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| | 8.2 | Tissues | 168 |
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| | 8.3 | Organ Systems | 175 |
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| | | 8.3.1 | The Cardiovascular System | 175 |
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| | | 8.3.2 | The Immune System | 178 |
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| | | 8.3.3 | The Nervous System | 181 |
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| | 8.4 | Systems Biology | 186 |
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| | 8.5 | Suggested Readings | 187 |
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| 9 | Disease and Its Treatment | 189 |
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| | 9.1 | General Principles of Pathology and Therapeutics | 190 |
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| | | 9.1.1 | Cellular Stress and Responses to It | 190 |
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| | | 9.1.2 | Cell Injury | 192 |
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| | | 9.1.3 | Cell Death | 193 |
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| | | 9.1.4 | General Principles of Therapeutics | 194 |
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| | 9.2 | Healing | 196 |
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| | 9.3 | Genetics and Disease | 198 |
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| | 9.4 | Infectious Disease and Antibiotics | 200 |
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| | 9.5 | Cardiovascular Disease | 201 |
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| | 9.6 | Cancer | 205 |
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| | 9.7 | Drug Discovery | 208 |
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| | 9.8 | Molecular Medicine | 211 |
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| | 9.9 | Suggested Readings | 212 |
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| 10 | Molecular Biotechnology | 215 |
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| | 10.1 | Molecular Instrumentation | 215 |
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| | | 10.1.1 | Measurements of Mass and Charge | 216 |
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| | | 10.1.2 | Macromolecular Structure Determination | 221 |
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| | | 10.1.3 | Assays of Molecular Activity | 233 |
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| | | 10.1.4 | Distribution of Molecules Through Space and Time | 224 |
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| | | 10.1.5 | Nucleic Acid Instrumentation | 225 |
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| | 10.2 | Model Organisms: Germs, Worms, Weeds, Bugs, and Rodents | 230 |
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| | | 10.2.1 | Escherichia coli | 232 |
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| | | 10.2.2 | Saccharomyces cerevisiae | 232 |
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| | | 10.2.3 | Arabidopsis thaliana | 233 |
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| | | 10.2.4 | Caenorhabditis elegans | 233 |
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| | | 10.2.5 | Drosophila melanogaster | 234 |
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| | | 10.2.6 | Danio rerio | 234 |
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| | | 10.2.7 | Mus musculus | 235 |
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| | 10.3 | Genetic Engineering | 235 |
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| | 10.4 | Molecular Biotechnology and Human Life | 238 |
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| | 10.5 | Suggested Readings | 239 |
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| 11 | Molecular Bioethics | 241 |
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| | 11.1 | Molecular Biology and Medicine | 242 |
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| | 11.2 | Molecular Biology and Agriculture | 245 |
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| | 11.3 | Molecular Biology and Society | 246 |
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| | 11.4 | Regulation and Control of Molecular Biotechnology | 249 |
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| | 11.5 | Learning about Life | 250 |
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| | 11.6 | Suggested Readings | 251 |
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| Glossary | 253 |
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| Index
Sample Chapter - Download PDF (157 KB) | 285 |
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