Using the tools of information technology to understand the molecular machinery of the cell offers both challenges and opportunities to computational scientists. Over the past decade, novel algorithms have been developed both for analyzing biological data and for synthetic biology problems such as protein engineering.
Chimeras and Consciousness begins the inquiry into the evolution of the collective sensitivities of life. Scientist-scholars from a range of fields—including biochemistry, cell biology, history of science, family therapy, genetics, microbial ecology, and primatology—trace the emergence and evolution of consciousness. Complex behaviors and the social imperatives of bacteria and other life forms during 3,000 million years of Earth history gave rise to mammalian cognition.
The results of fMRI brain scanning require extensive analysis in the laboratory. In Handling Digital Brains, Morana Alac shows that fMRI researchers do not sit passively staring at computer screens but actively involve their bodies in laboratory practice. Discussing fMRI visuals with colleagues, scientists animate the scans with gestures, and talk as they work with computers. Alač argues that to understand how digital scientific visuals take on meaning we must consider their dynamic coordination with gesture, speech, and working hands.
In 1995, John Maynard Smith and Eörs Szathmáry published their influential book The Major Transitions in Evolution. The "transitions" that Maynard Smith and Szathmáry chose to describe all constituted major changes in the kinds of organisms that existed but, most important, these events also transformed the evolutionary process itself. The evolution of new levels of biological organization, such as chromosomes, cells, multicelled organisms, and complex social groups radically changed the kinds of individuals natural selection could act upon.
In 1809—the year of Charles Darwin’s birth—Jean-Baptiste Lamarck published Philosophie zoologique, the first comprehensive and systematic theory of biological evolution. The Lamarckian approach emphasizes the generation of developmental variations; Darwinism stresses selection. Lamarck’s ideas were eventually eclipsed by Darwinian concepts, especially after the emergence of the Modern Synthesis in the twentieth century.
Information shapes biological organization in fundamental ways and at every organizational level. Because organisms use information—including DNA codes, gene expression, and chemical signaling—to construct, maintain, repair, and replicate themselves, it would seem only natural to use information-related ideas in our attempts to understand the general nature of living systems, the causality by which they operate, the difference between living and inanimate matter, and the emergence, in some biological species, of cognition, emotion, and language.
The molecular life sciences are making visible what was once invisible. Yet the more we learn about our own biology, the less we are able to fit this knowledge into an integrated whole. Life is divided into new sub-units and reassembled into new forms: from genes to clones, from embryonic stages to the building-blocks of synthetic biology.
The work performed by living systems ranges from photosynthesis to prodigious feats of computation and organization. This multidisciplinary volume explores work across many different levels of organization. By addressing how work gets done, and why, from the perspectives of research in a range of disciplines, including cellular and evolutionary biology, neuroscience, psychology, electrical and computer engineering, and design, the volume sets out to establish an integrative perspective on understanding work in living systems, including humans.
Although Hermann von Helmholtz was one of most remarkable figures of nineteenth-century science, he is little known outside his native Germany. Helmholtz (1821-1894) made significant contributions to the study of vision and perception and was also influential in the painting, music, and literature of the time; one of his major works analyzed tone in music.
Cartographic maps have guided our explorations for centuries, allowing us to navigate the world. Science maps have the potential to guide our search for knowledge in the same way, helping us navigate, understand, and communicate the dynamic and changing structure of science and technology. Allowing us to visualize scientific results, science maps help us make sense of the avalanche of data generated by scientific research today.
Why our dependence on coal-produced energy is bad for our health: a physician maps the connections of burning coal to death and disease.
An argument against the “lifeboat ethic” of contemporary bioethics that views medicine as a commodity rather than a tradition of care and caring.
Lynn MargulisCeleste A. AsikainenScientists elucidate the astounding collective sensory capacity of Earth and its evolution through time.
Two leading physicians’ prescription for solving our health care problems: organizing the fragmented system that delivers care.
Jeremy R. GarrettA balanced, accessible discussion of whether and on what grounds animal research can be ethically justified.
Lynn MargulisCeleste A. Asikainen
Jeremy R. Garrett
