Checkpoint Orientated Cell Cycle Modeling Issues in Simulation of Synchronized Situation

Jonathan Pascalie, Valérie Lobjois, Hervé Luga, Bernard Ducommun, Yves Duthen

Abstract

In this paper, the strengths of the checkpoint-orientated modeling in synchronizing cell population are highlighted. Through different experiments, this work shows how to synchronize a population of asynchronous and heterogeneous cells with our proposed model of cell cycle. We will show that the probabilistic modeling undertaken accurately reproduces the dynamics of cell population under specific environmental conditions.