The Brain in Motion
From Microcircuits to Global Brain Function
286 pp., 6 x 9 in, 73 color illus.
- Published: October 31, 2023
- Publisher: The MIT Press
An evolutionary perspective—from lampreys to humans—on how the forebrain coordinates movement while the networks in the brainstem and spinal cord handle the execution.
All living creatures interact with their environment: even the most basic have a set of innate motor circuits they rely on to feed, locomote, fight, and flee. In The Brain in Motion, Sten Grillner describes the evolution of the motor repertoire of vertebrates, from protovertebrates to primates. With breadth and depth, Grillner explores how the brain uses the different microcircuits in the brainstem and spinal cord, coordinating them through commands from the forebrain. He also considers the normal function of the brain as a platform for understanding clinical conditions such as stroke, Parkinson´s and Huntington´s diseases, and spinal cord injury.
Grillner also explains in The Brain in Motion how the remarkable finding that the lamprey forebrain has all the components of the mammalian one has radically changed scientists' views on the evolutionary origin of the vertebrate forebrain. We now know that the basic organization evolved 560 rather than 300 million years ago, as was previously thought. The forebrain, says Grillner, is like an orchestra conductor, while the microcircuits, with their reaching, grasping, posture, locomotion, and numerous other patterns of behavior, correspond to the members of the orchestra. The conductor determines when each will be called into action.
Providing an elegantly integrated perspective, The Brain in Motion is essential reading for anybody that works professionally with movement control and function and dysfunction, whether in basic research, clinically, or in the training of motor skills.
“Grillner's The Brain in Motion offers fundamental insights about motor control from a giant in the field who has a unique perspective on evolution and the power of modular design as observed in the brains of 'simple' vertebrates. The volume covers a remarkable range of the circuits and regions controlling movements, from spinal cord to cerebellum to basal ganglia to neocortex, conveyed with a clarity that opens up this domain to anyone interested in the brain and behavior. The chapter summaries give brilliantly condensed views and precious guides for the reader. A unique and valuable compendium that is a delight to read.”
Ann M. Graybiel, Institute Professor, MIT
“This unique and very personal book is a must read. It conveys the author's deep insight, makes the arch from historic background to latest research and crosses evolutionary boundaries.”
Silvia Arber, Professor in Neuroscience, Biozentrum and FMI, University of Basel, Switzerland