Changing Connectomes

Evolution, Development, and Dynamics in Network Neuroscience

By Marcus Kaiser

An up-to-date overview of the field of connectomics, introducing concepts and mechanisms underlying brain network change at different stages.

Overview

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Praise

Summary

An up-to-date overview of the field of connectomics, introducing concepts and mechanisms underlying brain network change at different stages.

The human brain undergoes massive changes during its development, from early childhood and the teenage years to adulthood and old age. Across a wide range of species, from C. elegans and fruit flies to mice, monkeys, and humans, information about brain connectivity (connectomes) at different stages is now becoming available. New approaches in network neuroscience can be used to analyze the topological, spatial, and dynamical organization of such connectomes. In Changing Connectomes, Marcus Kaiser provides an up-to-date overview of the field of connectomics and introduces concepts and mechanisms underlying brain network changes during evolution and development. 

Drawing on a range of results from experimental, clinical, and computational studies, Kaiser describes changes during healthy brain maturation and during brain network disorders (including such neurodevelopmental conditions as schizophrenia and depression), brain injury, and neurodegenerative disorders including dementia. He argues that brain stimulation is an area where understanding connectome development could help in assessing long-term effects of interventions. Changing Connectomes is a suitable starting point for researchers who are new to the field of connectomics, and also for researchers who are interested in the link between brain network organization and brain and cognitive development in health and disease. Matlab/Octave code examples available at the MIT Press website will allow computational neuroscience researchers to understand and extend the shown mechanisms of connectome development.

Hardcover

$45.00 X | £38.00 ISBN: 9780262044615 270 pp. | 7 in x 9 in 56 color illus.

Endorsements

  • A central focus of contemporary connectomics is on patterns of change—capturing how connectomes grow, mature, degenerate, evolve, adapt and reconfigure. This important book provides a comprehensive account of how these changes unfold, and how they relate to brain dynamics, cognition and behavior.

    Olaf Sporns

    Distinguished Professor, Indiana University; author of Networks of the Brain and Discovering the Human Connectome

  • From the wiring diagram of the worm nervous system through to the game-changing potential of big data and AI, the author clearly lays out basic principles and thoughtfully guides the reader through cutting-edge discoveries and future applications of the exploding science of brain connectomics.

    Heidi Johansen-Berg

    University of Oxford; author of Diffusion MRI