The Science and Ethics of Editing Humans
What does the birth of babies whose embryos have gone through genome editing mean—for science and for all of us?
In November 2018, the world was shocked to learn that two babies had been born in China with DNA edited while they were embryos—as dramatic a development in genetics as the 1996 cloning of Dolly the sheep. In this book, Hank Greely, a leading authority on law and genetics, tells the fascinating story of this human experiment and its consequences. Greely explains what Chinese scientist He Jiankui did, how he did it, and how the public and other scientists learned about and reacted to this unprecedented genetic intervention.
The two babies, nonidentical twin girls, were the first “CRISPR'd” people ever born (CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats, is a powerful gene-editing method). Greely not only describes He's experiment and its public rollout (aided by a public relations adviser) but also considers, in a balanced and thoughtful way, the lessons to be drawn both from these CRISPR'd babies and, more broadly, from this kind of human DNA editing—“germline editing” that can be passed on from one generation to the next.
Greely doesn't mince words, describing He's experiment as grossly reckless, irresponsible, immoral, and illegal. Although he sees no inherent or unmanageable barriers to human germline editing, he also sees very few good uses for it—other, less risky, technologies can achieve the same benefits. We should consider the implications carefully before we proceed.
Hardcover$27.95 T ISBN: 9780262044431 400 pp. | 5.375 in x 8 in 0
"Packed with facts and analysis, Henry Greely's CRISPR People examines what He did, explains why Greely believes it was wrong, describes the world's reaction, and details what we can and should do about work like this in the future...Greely provides an exquisite view of the wide-ranging issues at play in this particular case."
"In 'Crispr People,' law professor and bioethicist Henry Greely provides a more detailed framework for how to think about regulating to get the best out of Crispr, while avoiding a repeat of He's experiment with life."
“America's most quoted bioethicist has written the definitive guide to the international consensus against germline editing... and how it all came crashing down in November 2018. In a concise retelling that's part diary, part history, and part journalism, Hank Greely pieces together how a Chinese scientist defied bioethics—and common sense—to create the first gene-edited humans."
biomedicine editor, MIT Technology Review
“Hank Greely is a master of detail, and delivers an 'as if you were there' portrayal of events surrounding the announcement of the first children born with edited genomes. For anyone who wants to know how we got there, and where we go next, this is the book for you. With both nuance and wit, Greely makes you an expert, too."
R. Alta Charo
Warren P. Knowles Professor of Law, University of Wisconsin–Madison
“Hank Greely, a renowned authority on science and law, delves deeply into the complex, evolving world of human germline genome editing, offering a story rich in scientific fact, but also a fascinating portrayal of key players, critical turning points, and the promise and peril of this scientific advance."
Former FDA Commissioner