The Dynamic Neuron

The Dynamic Neuron

By John Smythies

A comprehensive review of current research on synaptic plasticity.

A Bradford Book





A comprehensive review of current research on synaptic plasticity.

The traditional model of synapses as fixed structures has been replaced by a dynamic one in which synapses are constantly being deleted and replaced. This book, written by a leading researcher on the neurochemistry of schizophrenia, integrates material from neuroscience and cell biology to provide a comprehensive account of our current knowledge of the neurochemical basis of synaptic plasticity.

The book presents the evidence for synaptic plasticity, an account of the dendritic spine and the glutamate synapse with a focus on redox mechanisms, and the biochemical basis of the Hebbian synapse. It discusses the role of endocytosis, special proteins, and local protein synthesis. Additional topics include volume transmission, arachidonic acid signaling, hormonal modulation, and psychological stress. Finally, the book considers pharmacological and clinical implications of current research, particularly with reference to schizophrenia and Alzheimer's disease.


$42.00 X ISBN: 9780262194730 160 pp. | 6 in x 9 in 15 illus.


  • A refreshing treatment of an important area of neuroscience.

    Mike Leski

    Department of Psychiatry, Harvard Medical School and McLean Hospital

  • This book provides an extensive review of the topic with much original perspective and discussion. Smythies' maverick statements are supported by reasonable evidence and argument.

    Ashley Bush

    Harvard University

  • Smythies provides a unique insight as well as much evidence for a biochemical basis for the formation and regression of synapses in the dynamic process of synaptic plasticity. The book will be particularly useful to a general scientific audience and will provide a platform for promoting and encouraging further research efforts by neuroscientists and cell biologists alike.

    Peter J. O'Brien

    Faculty of Pharmacy, University of Toronto