Skip navigation
Hardcover | $8.75 Short | £7.95 | 160 pp. | 6 x 9 in | 15 illus. | May 2002 | ISBN: 9780262194730
Mouseover for Online Attention Data

The Dynamic Neuron


The traditional model of synapses as fixed structures has been replaced by a dynamic one in which synapses are constantly being deleted and replaced. This book, written by a leading researcher on the neurochemistry of schizophrenia, integrates material from neuroscience and cell biology to provide a comprehensive account of our current knowledge of the neurochemical basis of synaptic plasticity.

The book presents the evidence for synaptic plasticity, an account of the dendritic spine and the glutamate synapse with a focus on redox mechanisms, and the biochemical basis of the Hebbian synapse. It discusses the role of endocytosis, special proteins, and local protein synthesis. Additional topics include volume transmission, arachidonic acid signaling, hormonal modulation, and psychological stress. Finally, the book considers pharmacological and clinical implications of current research, particularly with reference to schizophrenia and Alzheimer's disease.

About the Author

John Smythies was Professor Emeritus of Psychology at the University of California, San Diego, and at the Neurology Institute in London with appointments at Harvard and at the University of Washington, Seattle. He is one of the pre-eminent researchers who studies the neurochemistry of schizophrenia and mental illness.


“A refreshing treatment of an important area of neuroscience.”
Mike Leski, Department of Psychiatry, Harvard Medical School and McLean Hospital
“This book provides an extensive review of the topic with much original perspective and discussion. Smythies' maverick statements are supported by reasonable evidence and argument.”
Ashley Bush, Harvard University
“Smythies provides a unique insight as well as much evidence for a biochemical basis for the formation and regression of synapses in the dynamic process of synaptic plasticity. The book will be particularly useful to a general scientific audience and will provide a platform for promoting and encouraging further research efforts by neuroscientists and cell biologists alike.”
Peter J. O’Brien, Faculty of Pharmacy, University of Toronto