Skip navigation
Hardcover | Out of Print | April 1978 | ISBN: 9780262050203
Paperback | $20.00 X | £14.95 | March 1982 | ISBN: 9780262550079

The Mindful Brain

Cortical Organization and the Group-Selective Theory of Higher Brain Function


This significant contribution to neuroscience consists of two papers, the first by Mountcastle an, the second by Edelman. Between them, they examine from different but complementary directions the relationships that connect the higher brain--memory, learning, perception, thinking--with what goes on at the most basic levels of neural activity, with particular stress on the role of local neuronal circuits.Edelman's major hypothesis is that "the conscious state results from phasic reentrant signaling occurring in parallel processes that involve associations between stored patterns and current sensory or internal input." This selective process occurs by the polling of degenerate primary repertoires of neuronal groups that are formed during embryogenesis and development. Edelman's theory extrapolates to the brain the selectionistic immunological theories for which he was awarded the 1972 Nobel Prize in Physiology or Medicine.Mountcastle's paper reviews what is known about the actual structure of various parts of the neo cortex. He relates the large entities of the neocortex to their component modules--the local neuronal circuits--and shows how the complex interrelationships of such a distributed system can yield dynamic distributed functioning.There are strong conceptual parallels between Mountcastle's idea of cortical columns and their functional subunits and Edelman's concept of populations of neurons functioning as processors in a brain system based on selectional rather than instructional principles. These parallels are traced and put into perspective in Francis Schmitt's Introduction.


“"Each essay is superb in form and scholarship.... An important book that should be read by all interested in the topic." Choice
“"The Mindful Brain is a proposal by two eminent biological scientists for a mechanism whereby mind becomes manifest from the operations of brain tissue. The proposal is detailed and in many respects sophisticated. "Mountcastle, dean of American neurophysiologists, presents the case for a modular structure of the cerebral cortex.... "Edelman, a Nobel laureate, gives mathematical form to the proposed mechanism by applying to the functioning of the brain the theory of selection which he so successfully applied to immunological processes." Karl H. Pribram , Journal of Nervous and Mental Disease”