Until recently, genetic, neuroanatomical, and psychological investigations on neurodevelopmental disorders were carried out independently. Now, tremendous advances across all disciplines have brought us toward a new scientific frontier: the integration of molecular genetics with a developmental cognitive neuroscience. The goal is to understand the basic mechanisms by which genes and environmental processes contribute to the development of specific structures and regions of the brain.
This handbook-style volume explores these advances from the perspective of developmental disorders in children. Research on children with known genetic disorders offers insights into the genetic mechanisms that underlie neural development and organization, as expressed in variations in cognitive profiles. The contributions provide in-depth analyses of a broad range of neurodevelopmental disorders, including those resulting from whole chromosome defects (Down and Turner syndromes), those related to defects in a single gene (fragile-X syndrome) or a small number of genes (Williams syndrome), and complex genetic disorders (dyslexia, autism). Contributors from the fields of teratology and brain injury provide additional perspectives.
Contributors: Jane Adams, Marcia A. Barnes, Simon Baron-Cohen, Elizabeth Bates, Margaret L. Bauman, Ursula Bellugi, Jacquelyn Bertrand, Lori Buchanan, Merlin G. Butler, Dawn Delaney, Maureen Dennis, Kim N. Dietrich, Elizabeth M. Dykens, Jack M. Fletcher, Susan E. Folstein, Barbara R. Foorman, Albert Galaburda, Randi J. Hagerman, John Harrison, C. Ross Hetherington, Greg Hickok, Terry Jernigan, Beth Joseph, William E. MacLean, Jr., Michele M.M. Mazzocco, William M. McMahon, Carolyn B. Mervis, Debra Mills, Colleen A. Morris, Lynn Nadel, Bruce F. Pennington, Allan L. Reiss, Mabel L. Rice, Byron F. Robinson, Judith L. Ross, Joanne Rovet, Susan L. Santangelo, Bennett A. Shaywitz, Sally E. Shaywitz, Marian Sigman, Helen Tager-Flusberg, Travis Thompson, J. Bruce Tomblin, Doris Trauner, Stefano Vicari, Xuyang Zhang, Andrew Zinn.
“"This volume describes the current state of a new field for studying brain-behavior-mind relationships--the intersection of cognitive neuroscience and developmental psychopathology. The contributors demonstrate how rigorous research can illuminate clinical phenomena and dysfunctions, and how the careful dissection of clinical disorders can further the understanding of the normal development of brain and mind."”
—Donald J. Cohen, MD, Harris Professor of Child Psychiatry, Pediatrics and Psychology, Yale University, and Director, Yale Child Study Center
“"This book presents an enticing panorama of and is packed with information on the latest trends in developmental cognitive neuroscience. Helen Tager-Flusberg's book provides the most stimulating introduction available for this somewhat forbiddingly named new discipline. Learning about what can go wrong in brain development and the far-reaching consequences of even subtle brain abnormalities makes you marvel at what goes right. The budding researchers who will be reading this book should just itch to get their hands in to participate in the exciting endeavour to unravel the links between genes, mind, and brain. Anyone interested in developmental or abnormal psychology will realise how writers in the past have woefully ignored such links. This book puts developmental disorders into the proper multidisciplinary perspective. The well-chosen chapters cover a large variety of conditions. They provide new information on eventhe most familiar, such as Down syndrome, and introduce less well known conditions, such as developmental synesthesia. As a collection of up-to-date chapters, this book has no competition. For those who have been wondering what all the excitement in cognitive neuroscience is about, this is the perfect introduction."”
—Uta Frith, Professor of Cognitive Development at University College London, Institue of Cognitive Neuroscience
“"Tager-Flusberg's introductory chapter brilliantly sets the stage for a truly developmental approach to atypical phenotypes, and challenges theorists using adult neuropsychological data to situate the nature/nuture debate. The vast coverage of the book highlights the importance of the cognitive neuroscience approach to development. This is a must for theorists, researchers and practitioners alike."”
—Annette Karmiloff-Smith, Professor of Neurocognitive Development, Institute of Child Health