From Vienna Series in Theoretical Biology

Rethinking Cancer

A New Paradigm for the Postgenomics Era

Edited by Bernhard Strauss, Marta Bertolaso, Ingemar Ernberg and Mina J. Bissell

Leading scientists argue for a new paradigm for cancer research, proposing a complex systems view of cancer supported by empirical evidence.

Overview

Author(s)

Summary

Leading scientists argue for a new paradigm for cancer research, proposing a complex systems view of cancer supported by empirical evidence.

Current consensus in cancer research explains cancer as a disease caused by specific mutations in certain genes. After dramatic advances in genome sequencing, never before have we known so much about the individual cancer cell—and yet never before has it been so unclear how to use this knowledge for treatment success. In this volume, leading researchers argue for a new theory framework for understanding and treating cancer. The contributors propose a complex systems view of cancer, presenting conceptual building blocks for a new research paradigm supported by empirical evidence.

The contributors first discuss the new research framework in terms of theoretical foundations and then take up the relevance of a systems approach, reviewing such topics as nonlinearity, recurrence after treatment, the cellular attractor concept, network theory, and non-coding DNA—the “dark matter” of our genome. They address the temporality of cancer progression, drawing on evolutionary theory and clinical experience. Finally, they cover the dominant role of the tissue microenvironment in cancer, analyzing topics including altered metabolic pathways, the disease-defining influence on metastasis, and the interconnectedness of different environmental niches across levels of organization.

Hardcover

$60.00 X ISBN: 9780262045216 456 pp. | 7 in x 9 in 34 b&w illus.

Editors

Bernhard Strauss

Bernhard Strauss is Senior Research Associate in the Department of Biochemistry at the University of Cambridge.

Marta Bertolaso

Marta Bertolaso is Associate Professor of Philosophy of Science in the Faculty of Engineering at Università Campus Bio-Medico in Rome.

Ingemar Ernberg

Ingemar Ernberg is Professor of Tumor Biology at the Department of Microbiology, Tumor, and Cell Biology at the Karolinska Institutet in Stockholm.

Mina J. Bissell

Mina J. Bissell is Distinguished Scientist in the Biological Systems and Engineering Division at Lawrence Berkeley National Laboratory.