Today, translational neuroscience faces significant challenges. Available therapies to treat brain and nervous system disorders are extremely limited and dated, and further development has effectively ceased. Disinvestment by the private sector occurred just as promising new technologies in genomics, stem cell biology, and neuroscience emerged to offer new possibilities. In this volume, experts from both academia and industry discuss how novel technologies and reworked translation concepts can create a more effective translational neuroscience.
The contributors consider such topics as using genomics and neuroscience for better diagnostics and biomarker identification; new approaches to disease based on stem cell technology and more careful use of animal models; and greater attention to human biology and what it will take to make new therapies available for clinical use. They conclude with a conceptual roadmap for an effective and credible translational neuroscience—one informed by a disease-focused knowledge base and clinical experience.
Tobias M. Böckers, Thomas Bourgeron, Karl Broich, Nils Brose, Bruce N. Cuthbert, Ilka Diester, Gül Dölen, Guoping Feng, Richard Frackowiak, Raquel E. Gur, Stephan Heckers, Franz Hefti, David M. Holtzman, Steven E. Hyman, Nancy Ip, Cynthia Joyce, Tobias Kaiser, Edward H. Koo, Walter J. Koroshetz, Katja S. Kroker, Robert C. Malenka, Isabelle Mansuy, Eliezer, Masliah, Yuan Mei, Andreas Meyer-Lindenberg, Lennart Mucke, Pierluigi Nicotera, Karoly Nikolich, Michael J. Owen, Menelas N. Pangalos, Alvaro Pascual-Leone, Joel S. Perlmutter, Trevor W. Robbins, Lee L. Rubin, Akira Sawa, Mareike Schnaars, Bernd Sommer, Maria Grazia Spillantini, Laura Spinney, Matthew W. State, Marius Wernig
About the Editors
Karoly Nikolich is Consulting Professor in the Department of Psychiatry at Stanford University Medical School as well as Founder of Circuit Therapeutics and Chairman of Alkahest, two biotechnology companies that grew out of research done at Stanford.
Steven E. Hyman is Harvard University Distinguished Professor of Stem Cell and Regenerative Biology and Director of the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard.
—Eric Nestler, MD, PhD, Nash Family Professor, Director, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
—Eric M. Reiman, MD, Executive Director, Banner Alzheimer’s Institute
—Solomon H. Snyder, MD, Professor of Neuroscience, Johns Hopkins Medical School
—Steve Paul, MD, President and CEO, Voyager Therapeutics; Founder, SAGE Therapeutics and Tal Medical; former President, Lilly Research Laboratories; former Scientific Director, National Institute of Mental Health