Alvaro Pascual-Leone

Alvaro Pascual-Leone is Director of Research at the Behavioral Neurology Unit of Beth Israel Deaconess Medical Center and Associate Professor of Neurology at Harvard Medical School.

  • Transcranial Magnetic Stimulation

    Transcranial Magnetic Stimulation

    A Neurochronometrics of Mind

    Vincent Walsh and Alvaro Pascual-Leone

    The mainstays of brain imaging techniques have been positron emission tomography (PET), functional magnetic resonance imaging (fMRI), magnetoencephalography (MEG), and event-related potentials (ERPs). These methods all record direct or indirect measures of brain activity and correlate the activity patterns with behavior. But to go beyond the correlations established by these techniques and prove the necessity of an area for a given function, cognitive neuroscientists need to be able to reverse engineer the brain—i.e., to selectively remove components from information processing and assess their impact on the output.

    This book is about transcranial magnetic stimulation (TMS), a technique that emerged during the same period as neuroimaging and has made it possible to reverse engineer the human brain's role in behavioral and cognitive functions. The subject areas that can be studied using TMS run the gamut of cognitive psychology—attention, perception, awareness, eye movements, action selection, memory, plasticity, language, numeracy, and priming. The book presents an overview of historical attempts at magnetic brain stimulation, ethical considerations of the technique's use, basic technical and practical information, the results of numerous TMS studies, and a discussion of the future of TMS in the armamentarium of cognitive neuropsychology.

    • Hardcover $13.75 £10.99
    • Paperback $40.00 £32.00

Contributor

  • Is the Universe a Hologram?

    Is the Universe a Hologram?

    Scientists Answer the Most Provocative Questions

    Adolfo Plasencia

    Questions about the physical world, the mind, and technology in conversations that reveal a rich seam of interacting ideas.

    Science today is more a process of collaboration than moments of individual “eurekas.” This book recreates that kind of synergy by offering a series of interconnected dialogues with leading scientists who are asked to reflect on key questions and concepts about the physical world, technology, and the mind. These thinkers offer both specific observations and broader comments about the intellectual traditions that inform these questions; doing so, they reveal a rich seam of interacting ideas.

    The persistent paradox of our era is that in a world of unprecedented access to information, many of the most important questions remain unsolved. These conversations (conducted by a veteran science writer, Adolfo Plasencia) reflect this, with scientists addressing such issues as intelligence, consciousness, global warming, energy, technology, matter, the possibility of another earth, changing the past, and even the philosophical curveball, “is the universe a hologram?”

    The dialogues discuss such fascinating aspects of the physical world as the function of the quantum bit, the primordial cosmology of the universe, and the wisdom of hewn stones. They offer optimistic but reasoned views of technology, considering convergence culture, algorithms, “Beauty ≠ Truth,” the hacker ethic, AI, and other topics. And they offer perspectives from a range of disciplines on intelligence, discussing subjects that include the neurophysiology of the brain, affective computing, collaborative innovation, and the wisdom of crowds.

    Conversations with Hal Abelson, Ricardo Baeza-Yates, John Perry Barlow, Javier Benedicto, José Bernabéu, Michail Bletsas, Jose M. Carmena, David Casacuberta, Yung Ho Chang, Ignacio Cirac, Gianluigi Colalucci, Avelino Corma, Bernardo Cuenca Grau, Javier Echeverria, José Hernández-Orallo, Hiroshi Ishii, Pablo Jarillo-Herrero, Henry Jenkins, Anne Margulies, Mario J. Molina, Tim O'Reilly, John Ochsendorf, Paul Osterman, Alvaro Pascual-Leone, Rosalind W. Picard, Howard Rheingold, Alejandro W. Rodriguez, Israel Ruiz, Sara Seager, Richard Stallman, Antonio Torralba, Bebo White, José María Yturralde

    • Hardcover $19.95 £15.99
    • Paperback $19.95 £15.99
  • Translational Neuroscience

    Translational Neuroscience

    Toward New Therapies

    Karoly Nikolich and Steven E. Hyman

    Experts from academia and industry discuss how to create a new, more effective translational neuroscience drawing on novel technology and recent discoveries.

    Today, translational neuroscience faces significant challenges. Available therapies to treat brain and nervous system disorders are extremely limited and dated, and further development has effectively ceased. Disinvestment by the private sector occurred just as promising new technologies in genomics, stem cell biology, and neuroscience emerged to offer new possibilities. In this volume, experts from both academia and industry discuss how novel technologies and reworked translation concepts can create a more effective translational neuroscience.

    The contributors consider such topics as using genomics and neuroscience for better diagnostics and biomarker identification; new approaches to disease based on stem cell technology and more careful use of animal models; and greater attention to human biology and what it will take to make new therapies available for clinical use. They conclude with a conceptual roadmap for an effective and credible translational neuroscience—one informed by a disease-focused knowledge base and clinical experience.

    Contributors Tobias M. Böckers, Thomas Bourgeron, Karl Broich, Nils Brose, Bruce N. Cuthbert, Ilka Diester, Gül Dölen, Guoping Feng, Richard Frackowiak, Raquel E. Gur, Stephan Heckers, Franz Hefti, David M. Holtzman, Steven E. Hyman, Nancy Ip, Cynthia Joyce, Tobias Kaiser, Edward H. Koo, Walter J. Koroshetz, Katja S. Kroker, Robert C. Malenka, Isabelle Mansuy, Eliezer, Masliah, Yuan Mei, Andreas Meyer-Lindenberg, Lennart Mucke, Pierluigi Nicotera, Karoly Nikolich, Michael J. Owen, Menelas N. Pangalos, Alvaro Pascual-Leone, Joel S. Perlmutter, Trevor W. Robbins, Lee L. Rubin, Akira Sawa, Mareike Schnaars, Bernd Sommer, Maria Grazia Spillantini, Laura Spinney, Matthew W. State, Marius Wernig

    • Hardcover $55.00 £45.00