James MacKillop

James MacKillop is Associate Professor in the Department of Psychology at the University of Georgia, where he is also Associate Director of the William and Barbara Owens Institute for Behavioral Research, and Adjunct Associate Professor in the Department of Behavioral and Social Sciences at Brown University.

  • Genetic Influences on Addiction

    Genetic Influences on Addiction

    An Intermediate Phenotype Approach

    James MacKillop and Marcus R. Munafò

    A comprehensive review of research examining intermediary mechanisms to understand the link between genetic variation and addiction liability.

    Although there is scientific consensus that genetic factors play a substantial role in an individual's vulnerability to drug or alcohol addiction, specific genetic variables linked to risk or resilience remain elusive. Understanding how genetic factors contribute to addiction may require focusing on intermediary mechanisms, or intermediate phenotypes, that connect genetic variation and risk for addiction. This book offers a comprehensive review of this mechanistic-centered approach and the most promising intermediate phenotypes identified in empirical research.

    The contributors first consider the most established findings in the field, including variability in drug metabolism, brain electrophysiological profiles, and subjective reactions to direct drug effects; they go on to review highly promising areas such as expectancies, attentional processing, and behavioral economic variables; and finally, they investigate more exploratory approaches, including the differential susceptibility hypothesis and epigenetic modifications. Taken together, the chapters offer a macro-level testing of the hypothesis that these alternative, mechanistic phenotypes can advance the understanding of genetic influences on addiction. The book will be of interest to researchers and practitioners in a range of disciplines, including behavioral genetics, psychology, pharmacology, neuroscience, and sociology.

    Contributors John Acker, Steven R.H. Beach, Gene H. Brody, Angela D. Bryan, Megan J. Chenoweth, Danielle M. Dick, Eske D. Derks, Mary-Anne Enoch, Meg Gerrard, Frederick X. Gibbons, Thomas E. Gladwin, Mark S. Goldman, Marcus Heilig, Kent E. Hutchison, Hollis C. Karoly, Steven M. Kogan, Man Kit Lei, Susan Luczak, James MacKillop, Renee E. Magnan, Leah M. Mayo, Marcus R. Munafò, Daria Orlowska, Abraham A. Palmer, Danielle Pandika, Clarissa C. Parker, Robert A. Philibert, Lara A. Ray, Richard R. Reich, Ronald L. Simons, Courtney J. Stevens, Rachel E. Thayer, Rachel F. Tyndale, Tamara L. Wall, Reinout W. Wiers, Michael Windle, Harriet de Wit

    • Hardcover $10.75 £8.99

Contributor

  • What Is Addiction?

    What Is Addiction?

    Don Ross, Harold Kincaid, David Spurrett, and Peter Collins

    Leading addiction researchers survey the latest findings in addiction science, countering the simplistic cultural stereotypes of the addict.

    The image of the addict in popular culture combines victimhood and moral failure; we sympathize with addicts in films and novels because of their suffering and their hard-won knowledge. And yet actual scientific knowledge about addiction tends to undermine this cultural construct. In What Is Addiction?, leading addiction researchers from neuroscience, psychology, genetics, philosophy, economics, and other fields survey the latest findings in addiction science. They discuss such questions as whether addiction is one kind of condition, or several; if addiction is neurophysiological, psychological, or social, or incorporates aspects of all of these; to what extent addicts are responsible for their problems, and how this affects health and regulatory policies; and whether addiction is determined by inheritance or environment or both. The chapter authors discuss the possibility of a unifying basis for different addictions (considering both substance addiction and pathological gambling), offering both neurally and neuroscientifically grounded accounts as well as discussions of the social context of addiction. There can be no definitive answer yet to the question posed by the title of this book; but these essays demonstrate a sweeping advance over the simplistic conception embedded in popular culture.

    Contributors George Ainslie, Jennifer D. Bellegarde, Warren K. Bickel, Jennifer Bramen, Karen O. Brandon, Arthur Brody, Peter Collins, Jack Darkes, Mark S. Goldman, Gene M. Heyman, Harold Kincaid, Edythe D. London, James MacKillop, Traci Man, Neil Manson, John E. McGeary, John R. Monterosso, Ben Murrell, Nancy M. Petry, Marc N. Potenza, Howard Rachlin, Lara A. Ray, A. David Redish, Richard R. Reich, Don Ross, Timothy Schroeder, David Spurrett, Jackie Sullivan, Golnaz Tabibni, Andrew Ward, Richard Yi

    • Paperback $50.00 £40.00