Leo M. Chalupa

Leo M. Chalupa is Vice President for Research and Professor of Pharmacology and Physiology at George Washington University.

  • The New Visual Neurosciences

    The New Visual Neurosciences

    John S. Werner and Leo M. Chalupa

    A comprehensive review of contemporary research in the vision sciences, reflecting the rapid advances of recent years.

    Visual science is the model system for neuroscience, its findings relevant to all other areas. This essential reference to contemporary visual neuroscience covers the extraordinary range of the field today, from molecules and cell assemblies to systems and therapies. It provides a state-of-the art companion to the earlier book The Visual Neurosciences (MIT Press, 2003). This volume covers the dramatic advances made in the last decade, offering new topics, new authors, and new chapters.

    The New Visual Neurosciences assembles groundbreaking research, written by international authorities. Many of the 112 chapters treat seminal topics not included in the earlier book. These new topics include retinal feature detection; cortical connectomics; new approaches to mid-level vision and spatiotemporal perception; the latest understanding of how multimodal integration contributes to visual perception; new theoretical work on the role of neural oscillations in information processing; and new molecular and genetic techniques for understanding visual system development. An entirely new section covers invertebrate vision, reflecting the importance of this research in understanding fundamental principles of visual processing. Another new section treats translational visual neuroscience, covering recent progress in novel treatment modalities for optic nerve disorders, macular degeneration, and retinal cell replacement. The New Visual Neurosciences is an indispensable reference for students, teachers, researchers, clinicians, and anyone interested in contemporary neuroscience.

    Associate Editors Marie Burns, Joy Geng, Mark Goldman, James Handa, Andrew Ishida, George R. Mangun, Kimberley McAllister, Bruno Olshausen, Gregg Recanzone, Mandyam Srinivasan, W.Martin Usrey, Michael Webster, David Whitney

    Sections Retinal Mechanisms and ProcessesOrganization of Visual PathwaysSubcortical ProcessingProcessing in Primary Visual CortexBrightness and ColorPattern, Surface, and ShapeObjects and ScenesTime, Motion, and DepthEye MovementsCortical Mechanisms of Attention, Cognition, and Multimodal IntegrationInvertebrate VisionTheoretical PerspectivesMolecular and Developmental ProcessesTranslational Visual Neuroscience

    • Hardcover $275.00 £212.00
  • Cerebral Plasticity

    Cerebral Plasticity

    New Perspectives

    Leo M. Chalupa, Nicoletta Berardi, Matteo Caleo, Lucia Galli-Resta, and Tommaso Pizzorusso

    A survey of the latest research, covering such topics as plasticity in the adult brain and the underlying mechanisms of plasticity.

    The notion that neurons in the living brain can change in response to experience—a phenomenon known as "plasticity"—has become a major conceptual issue in neuroscience research as well as a practical focus for the fields of neural rehabilitation and neurodegenerative disease. Early work dealt with the plasticity of the developing brain and demonstrated the critical role played by sensory experience in normal development. Two broader themes have emerged in recent studies: the plasticity of the adult brain (one of the most rapidly developing areas of current research) and the search for the underlying mechanisms of plasticity—explanations for the cellular, molecular, and epigenetic factors controlling plasticity. Many scientists believe that achieving a fundamental understanding of what underlies neuronal plasticity could help us treat neurological disorders and even improve the learning capabilities of the human brain.

    This volume offers contributions from leaders in the field that cover all three approaches to the study of cerebral plasticity. Chapters treat normal development and the influences of environmental manipulations; cerebral plasticity in adulthood; and underlying mechanisms of plasticity. Other chapters deal with plastic changes in neurological conditions and with the enhancement of plasticity as a strategy for brain repair.

    • Hardcover $19.75 £14.99
  • Eye, Retina, and Visual System of the Mouse

    Eye, Retina, and Visual System of the Mouse

    Leo M. Chalupa and Robert W. Williams

    A comprehensive guide to current research, reflecting recent technical breakthroughs that have established the usefulness of the mouse model as part of a bilateral exchange between experimental and clinical research.

    Recent years have seen a burst of studies on the mouse eye and visual system, fueled in large part by the relatively recent ability to produce mice with precisely defined changes in gene sequence. Mouse models have contributed to a wide range of scientific breakthroughs for a number of ocular and neurological diseases and have allowed researchers to address fundamental issues that were difficult to approach with other experimental models. This comprehensive guide to current research captures the first wave of studies in the field, with fifty-nine chapters by leading scholars that demonstrate the usefulness of mouse models as a bridge between experimental and clinical research. The opening chapters introduce the mouse as a species and research model, discussing such topics as the mouse's evolutionary history and the mammalian visual system. Subsequent sections explore more specialized subjects, considering optics, psychophysics, and the visual behaviors of mice; the organization of the adult mouse eye and central visual system; the development of the mouse eye (including comparisons to human development); the development and plasticity of retinal projections and visuotopic maps; mouse models for human eye disease (including glaucoma and cataracts); and the application of advanced genomic technologies (including gene therapy and genetic knockouts) to the mouse visual system. Readers of this unique reference will see that the study of mouse models has already demonstrated real translational prowess in vision research.

    • Hardcover $19.75 £14.99
  • The Visual Neurosciences, 2-vol. set

    The Visual Neurosciences, 2-vol. set

    Leo M. Chalupa and John S. Werner

    An essential reference book for visual science.

    Visual science is the model system for neuroscience, its findings relevant to all other areas. This massive collection of papers by leading researchers in the field will become an essential reference for researchers and students in visual neuroscience, and will be of importance to researchers and professionals in other disciplines, including molecular and cellular biology, cognitive science, ophthalmology, psychology, computer science, optometry, and education.

    Over 100 chapters cover the entire field of visual neuroscience, from its historical foundations to the latest research and findings in molecular mechanisms and network modeling. The book is organized by topic—different sections cover such subjects as the history of vision science; developmental processes; retinal mechanisms and processes; organization of visual pathways; subcortical processing; processing in the primary visual cortex; detection and sampling; brightness and color; form, shape, and object recognition; motion, depth, and spatial relationships; eye movements; attention and cognition; and theoretical and computational perspectives. The list of contributors includes leading international researchers in visual science.

    • Hardcover $19.75 £14.99


  • The Cognitive Neuroscience of Mind

    The Cognitive Neuroscience of Mind

    A Tribute to Michael S. Gazzaniga

    Patricia A. Reuter-Lorenz, Kathleen Baynes, George R. Mangun, and Elizabeth A. Phelps

    Leaders in the cognitive neurosciences address a variety of topics in the field and reflect on Michael Gazzaniga's pioneering work and enduring influence.

    These essays on a range of topics in the cognitive neurosciences report on the progress in the field over the twenty years of its existence and reflect the many groundbreaking scientific contributions and enduring influence of Michael Gazzaniga, "the godfather of cognitive neuroscience"—founder of the Cognitive Neuroscience Society, founding editor of the Journal of Cognitive Neuroscience, and editor of the major reference work, The Cognitive Neurosciences, now in its fourth edition (MIT Press, 2009). The essays, grouped into four sections named after four of Gazzaniga's books, combine science and memoir in varying proportions, and offer an authoritative survey of research in cognitive neuroscience. "The Bisected Brain" examines hemispheric topics pioneered by Gazzaniga at the start of his career; "The Integrated Mind" explores the theme of integration by domination; the wide-ranging essays in "The Social Brain" address subjects from genes to neurons to social conversations and networks; the topics explored in "Mind Matters" include evolutionary biology, methodology, and ethics.

    Contributors Kathleen Baynes, Giovanni Berlucchi, Leo M. Chalupa, Mark D'Esposito, Margaret G. Funnell, Mitchell Glickstein, Scott A. Guerin, Todd F. Heatherton, Steven A. Hillyard, William Hirst, Alan Kingstone, Stephen M. Kosslyn, Marta Kutas, Elisabetta Làdavas, Joseph Ledoux, George R. Mangun, Michael B. Miller, Elizabeth A. Phelps, Steven Pinker, Michael I. Posner, Patricia A. Reuter-Lorenz, Mary K. Rothbart, Andrea Serino, Brad E. Sheese

    • Hardcover $8.75 £6.99
  • The Cognitive Neurosciences, Fourth Edition

    The Cognitive Neurosciences, Fourth Edition

    Michael S. Gazzaniga

    The fourth edition of the work that defines the field of cognitive neuroscience, offering completely new material.

    Each edition of this classic reference has proved to be a benchmark in the developing field of cognitive neuroscience. The fourth edition of The Cognitive Neurosciences continues to chart new directions in the study of the biologic underpinnings of complex cognition—the relationship between the structural and physiological mechanisms of the nervous system and the psychological reality of the mind. The material in this edition is entirely new, with all chapters written specifically for it.

    Since the publication of the third edition, the field of cognitive neuroscience has made rapid and dramatic advances; fundamental stances are changing and new ideas are emerging. This edition reflects the vibrancy of the field, with research in development and evolution that finds a dynamic growth pattern becoming specific and fixed, and research in plasticity that sees the neuronal systems always changing; exciting new empirical evidence on attention that also verifies many central tenets of longstanding theories; work that shows the boundaries of the motor system pushed further into cognition; memory research that, paradoxically, provides insight into how humans imagine future events; pioneering theoretical and methodological work in vision; new findings on how genes and experience shape the language faculty; new ideas about how the emotional brain develops and operates; and research on consciousness that ranges from a novel mechanism for how the brain generates the baseline activity necessary to sustain conscious experience to a bold theoretical attempt to make the problem of qualia more tractable.

    • Hardcover $39.75 £30.00