Miles A. Whittington

  • Fast Oscillations in Cortical Circuits

    Fast Oscillations in Cortical Circuits

    Roger D. Traub, Miles A. Whittington, and John G. R. Jefferys

    The study of cortical oscillations is of great interest to those working in many areas of neuroscience. A fast coherent EEG rhythm called gamma or "40 Hz" has been implicated in cognition, as it may play a role in binding together features of objects. This rhythm may also be important for consciousness, as a number of drugs that induce general anesthesia disrupt the synchronization of the rhythm at clinically relevant concentrations. There is also suggestive evidence implicating dysfunction of gamma rhythms in Alzheimer's disease, and perhaps in other neuropsychiatric disorders.

    In Fast Oscillations in Cortical Circuits, the authors use a combination of electrophysiological and computer modeling techniques to analyze how large networks of neurons can produce both epileptic seizures and functionally relevant synchronized oscillations. Specific topics covered include single hippocampal pyramid cells, hippocampal interneurons, synaptic interactions, gamma oscillations in brain slices as well as in vivo, the mechanisms of oscillation-synchronization (both local and long-range), the switch from gamma to beta frequencies and its implications for memory, and the significance of gamma oscillations for brain function.

    • Hardcover $68.00


  • Dynamic Coordination in the Brain

    Dynamic Coordination in the Brain

    From Neurons to Mind

    Christoph von der Malsburg, William A. Phillips, and Wolf Singer

    An examination of how widely distributed and specialized activities of the brain are flexibly and effectively coordinated.

    A fundamental shift is occurring in neuroscience and related disciplines. In the past, researchers focused on functional specialization of the brain, discovering complex processing strategies based on convergence and divergence in slowly adapting anatomical architectures. Yet for the brain to cope with ever-changing and unpredictable circumstances, it needs strategies with richer interactive short-term dynamics. Recent research has revealed ways in which the brain effectively coordinates widely distributed and specialized activities to meet the needs of the moment. This book explores these findings, examining the functions, mechanisms, and manifestations of distributed dynamical coordination in the brain and mind across different species and levels of organization. The book identifies three basic functions of dynamic coordination: contextual disambiguation, dynamic grouping, and dynamic routing. It considers the role of dynamic coordination in temporally structured activity and explores these issues at different levels, from synaptic and local circuit mechanisms to macroscopic system dynamics, emphasizing their importance for cognition, behavior, and psychopathology.

    Contributors Evan Balaban, György Buzsáki, Nicola S. Clayton, Maurizio Corbetta, Robert Desimone, Kamran Diba, Shimon Edelman, Andreas K. Engel, Yves Fregnac, Pascal Fries, Karl Friston, Ann Graybiel, Sten Grillner, Uri Grodzinski, John-Dylan Haynes, Laurent Itti, Erich D. Jarvis, Jon H. Kaas, J.A. Scott Kelso, Peter König, Nancy J. Kopell, Ilona Kovács, Andreas Kreiter, Anders Lansner, Gilles Laurent, Jörg Lücke, Mikael Lundqvist, Angus MacDonald, Kevan Martin, Mayank Mehta, Lucia Melloni, Earl K. Miller, Bita Moghaddam, Hannah Monyer, Edvard I. Moser, May-Britt Moser, Danko Nikolic, William A. Phillips, Gordon Pipa, Constantin Rothkopf, Terrence J. Sejnowski, Steven M. Silverstein, Wolf Singer, Catherine Tallon-Baudry, Roger D. Traub, Jochen Triesch, Peter Uhlhaas, Christoph von der Malsburg, Thomas Weisswange, Miles Whittington, Matthew Wilson

    • Hardcover $45.00