Sten Grillner

Sten Grillner is Director of the Nobel Institute for Neurophysiology at the Karolinska Institutet in Stockholm.

  • Microcircuits

    Microcircuits

    The Interface between Neurons and Global Brain Function

    Sten Grillner and Ann M Graybiel

    Leading neuroscientists discuss the function of microcircuits, functional modules that act as elementary processing units bridging single cells to systems and behavior.

    Microcircuits, functional modules that act as elementary processing units bridging single cells to systems and behavior, could provide the link between neurons and global brain function. Microcircuits are designed to serve particular functions; examples of these functional modules include the cortical columns in sensory cortici, glomeruli in the olfactory systems of insects and vertebrates, and networks generating different aspects of motor behavior. In this Dahlem Workshop volume, leading neuroscientists discuss how microcircuits work to bridge the single cell and systems levels and compare the intrinsic function of microcircuits with their ion channel subtypes, connectivity, and receptors, in order to understand the design principles and function of the microcircuits.

    The chapters cover the four major areas of microcircuit research: motor systems, including locomotion, respiration, and the saccadic eye movements; the striatum, the largest input station of the basal ganglia; olfactory systems and the neural organization of the glomeruli; and the neocortex. Each chapter is followed by a group report, a collaborative discussion among senior scientists.

    Contributors Lidia Alonso-Nanclares, Hagai Bergman, Maria Blatow, J. Paul Bolam, Ansgar Büschges, Antonio Caputi, Jean-Pierre Changeux, Javier DeFelipe, Carsten Duch, Paul Feinstein, Stuart Firestein, Yves Frégnac, Rainer W. Friedrich, C. Giovanni Galizia, Ann M. Graybiel, Charles A. Greer, Sten Grillner, Tadashi Isa, Ole Kiehn, Minoru Kimura, Anders Lanser, Gilles Laurent, Pierre-Marie Lledo, Wolfgang Maass, Henry Markram, David A. McCormick, Christoph M. Michel, Peter Mombaerts, Hannah Monyer, Hans-Joachim Pflüger, Dietmar Plenz, Diethelm W. Richter, Silke Sachse, H. Sebastian Seung, Keith T. Sillar, Jeffrey C. Smith, David L. Sparks, D. James Surmeier, Eörs Szathmáry, James M. Tepper, Jeff R. Wickens, Rafael Yuste

    • Hardcover $12.75 £10.99
  • Neurons, Networks, and Motor Behavior

    Neurons, Networks, and Motor Behavior

    Sten Grillner, Allen I. Selverston, Paul S.G. Stein, and Douglas G. Stuart

    Recent advances in motor behavior research rely on detailed knowledge of the characteristics of the neurons and networks that generate motor behavior. At the cellular level, Neurons, Networks, and Motor Behavior describes the computational characteristics of individual neurons and how these characteristics are modified by neuromodulators. At the network and behavioral levels, the volume discusses how network structure is dynamically modulated to produce adaptive behavior. Comparisons of model systems throughout the animal kingdom provide insights into general principles of motor control. Contributors describe how networks generate such motor behaviors as walking, swimming, flying, scratching, reaching, breathing, feeding, and chewing. An emerging principle of organization is that nervous systems are remarkably efficient in constructing neural networks that control multiple tasks and dynamically adapt to change.The volume contains six sections: selection and initiation of motor patterns; generation and formation of motor patterns: cellular and systems properties; generation and formation of motor patterns: computational approaches; modulation and reconfiguration; short-term modulation of pattern generating circuits; and sensory modification of motor output to control whole body orientation.

    • Hardcover $85.00
    • Paperback $9.75 £7.99

Contributor

  • Dynamic Coordination in the Brain

    Dynamic Coordination in the Brain

    From Neurons to Mind

    Christoph von der Malsburg, William A. Phillips, and Wolf Singer

    An examination of how widely distributed and specialized activities of the brain are flexibly and effectively coordinated.

    A fundamental shift is occurring in neuroscience and related disciplines. In the past, researchers focused on functional specialization of the brain, discovering complex processing strategies based on convergence and divergence in slowly adapting anatomical architectures. Yet for the brain to cope with ever-changing and unpredictable circumstances, it needs strategies with richer interactive short-term dynamics. Recent research has revealed ways in which the brain effectively coordinates widely distributed and specialized activities to meet the needs of the moment. This book explores these findings, examining the functions, mechanisms, and manifestations of distributed dynamical coordination in the brain and mind across different species and levels of organization. The book identifies three basic functions of dynamic coordination: contextual disambiguation, dynamic grouping, and dynamic routing. It considers the role of dynamic coordination in temporally structured activity and explores these issues at different levels, from synaptic and local circuit mechanisms to macroscopic system dynamics, emphasizing their importance for cognition, behavior, and psychopathology.

    Contributors Evan Balaban, György Buzsáki, Nicola S. Clayton, Maurizio Corbetta, Robert Desimone, Kamran Diba, Shimon Edelman, Andreas K. Engel, Yves Fregnac, Pascal Fries, Karl Friston, Ann Graybiel, Sten Grillner, Uri Grodzinski, John-Dylan Haynes, Laurent Itti, Erich D. Jarvis, Jon H. Kaas, J.A. Scott Kelso, Peter König, Nancy J. Kopell, Ilona Kovács, Andreas Kreiter, Anders Lansner, Gilles Laurent, Jörg Lücke, Mikael Lundqvist, Angus MacDonald, Kevan Martin, Mayank Mehta, Lucia Melloni, Earl K. Miller, Bita Moghaddam, Hannah Monyer, Edvard I. Moser, May-Britt Moser, Danko Nikolic, William A. Phillips, Gordon Pipa, Constantin Rothkopf, Terrence J. Sejnowski, Steven M. Silverstein, Wolf Singer, Catherine Tallon-Baudry, Roger D. Traub, Jochen Triesch, Peter Uhlhaas, Christoph von der Malsburg, Thomas Weisswange, Miles Whittington, Matthew Wilson

    • Hardcover $19.75 £15.99