Although there is scientific consensus that genetic factors play a substantial role in an individual's vulnerability to drug or alcohol addiction, specific genetic variables linked to risk or resilience remain elusive. Understanding how genetic factors contribute to addiction may require focusing on intermediary mechanisms, or intermediate phenotypes, that connect genetic variation and risk for addiction. This book offers a comprehensive review of this mechanistic-centered approach and the most promising intermediate phenotypes identified in empirical research.
Engineering has been an essential collaborator in biological research and breakthroughs in biology are often enabled by technological advances. Decoding the double helix structure of DNA, for example, only became possible after significant advances in such technologies as X-ray diffraction and gel electrophoresis. Diagnosis and treatment of tuberculosis improved as new technologies—including the stethoscope, the microscope, and the X-ray—developed.
Emil du Bois-Reymond is the most important forgotten intellectual of the nineteenth century. In his own time (1818–1896) du Bois-Reymond grew famous in his native Germany and beyond for his groundbreaking research in neuroscience and his provocative addresses on politics and culture. This biography by Gabriel Finkelstein draws on personal papers, published writings, and contemporary responses to tell the story of a major scientific figure.
In The New Science of Cities, Michael Batty suggests that to understand cities we must view them not simply as places in space but as systems of networks and flows. To understand space, he argues, we must understand flows, and to understand flows, we must understand networks—the relations between objects that comprise the system of the city.
Federal regulations that govern research misconduct in biomedicine have not been able to prevent an ongoing series of high-profile cases of fabricating, falsifying, or plagiarizing scientific research. In this book, Barbara Redman looks critically at current research misconduct policy and proposes a new approach that emphasizes institutional context and improved oversight.
Thanks to advances in molecular science and microscopy, we can visualize matter on a nanoscale, and structures not visible to the naked eye can be visualized and characterized. The fact that technology allows us to transcend the limits of natural perception and see what was previously unseeable creates a new dimension of aesthetic experience and practice: molecular aesthetics. This book, drawing on an exhibit and symposium at ZKM | Center for Art and Media Karlsruhe, documents aesthetic developments in what Félix Guattari called the “molecular revolution.”
In The Techno-Human Condition, Braden Allenby and Daniel Sarewitz explore what it means to be human in an era of incomprehensible technological complexity and change. They argue that if we are to have any prospect of managing that complexity, we will need to escape the shackles of current assumptions about rationality, progress, and certainty, even as we maintain a commitment to fundamental human values.
Viewed from above, Greenland offers an endless vista of whiteness interrupted only by scattered ponds of azure-colored melt water. Ninety percent of Greenland is covered by ice; its ice sheet, the largest outside Antarctica, stretches almost 1,000 miles from north to south and 600 miles from east to west. But this stark view of ice and snow is changing—and changing rapidly. Greenland’s ice sheet is melting; the dazzling, photogenic display of icebergs breaking off Greenland’s rapidly melting glaciers has become a tourist attraction.
On September 2, 1971, the chemist Paul Lauterbur had an idea that would change the practice of medical research. Considering recent research findings about the use of nuclear magnetic resonance (NMR) signals to detect tumors in tissue samples, Lauterbur realized that the information from NMR signals could be recovered in the form of images—and thus obtained noninvasively from a living subject. It was an unexpected epiphany: he was eating a hamburger at the time. Lauterbur rushed out to buy a notebook in which to work out his idea; he completed his notes a few days later.
What Science, Mathematics, and Logic Cannot Tell Us
Many books explain what is known about the universe. This book investigates what cannot be known. Rather than exploring the amazing facts that science, mathematics, and reason have revealed to us, this work studies what science, mathematics, and reason tell us cannot be revealed. In The Outer Limits of Reason, Noson Yanofsky considers what cannot be predicted, described, or known, and what will never be understood. He discusses the limitations of computers, physics, logic, and our own thought processes.