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Pages 144-150
First published 2 September 2013

An artificial lizard regrows its tail (and more): regeneration of 3-dimensional structures with hundreds of thousands of artificial cells

Alessandro Fontana, Borys Wrobel


Biological multicellular structures can not only self-generate from a single cell but also self-regenerate after damage. In this paper we investigate self-regeneration in a model of artificial development, Epigenetic Tracking. 3-dimensional cellular structures grown using our model reach a size and a level of complexity unmatched by other models in the field, thanks to several features of Epigenetic Tracking. One of these features is that only a small fraction of cells in the body, called drivers, orchestrate development. In this paper we use the mechanim for the generation of drivers based on the diffusion of morphogens as a foundation of several new mechanisms in Epigenetic Tracking, and show that these mechanisms allow for self-regeneration after removal of arbitrarily large portions of the multicellular body.