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DOI: http://dx.doi.org/10.7551/978-0-262-33027-5-ch004
Page 13
First published 20 July 2015

Do Endothelial Cells Dream of Eclectic Shape?

Katie Bentley

Abstract

Endothelial cells (ECs) line blood vessels and exhibit dramatic plasticity and diversity of form/behavior at the individual and collective cell levels. ECs coordinate in space and time to extend new blood vessel networks into tissues low in oxygen. Using examples from our integrated research program, we will describe how the Artificial Life perspective and approaches can be utilized to drive entirely new experimental biology based discoveries by capitalizing on the emergent behavior, predictive capacity and testable nature of agent-based models in close combination with in vitro and in vivo experiments.