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First published 20 July 2015

Simulation-Based Analysis of in Situ Cellular Motility

Mark Read, Jon Timmis, and Tatyana Chtanova

Abstract (Excerpt)

A fundamental challenge in simulation-based investigation of biological systems is deciding how detailed to make the simulation. Here we present a methodology that uses an automated simulation parameterisation technique to guide simulation development to an appropriate level of abstraction. We demonstrate the methodology in the context of simulating cellular motility. Recent advances in modern day imaging technology allow for the in situ examination of individual cell’s migration through tissues. Complex and sometimes highly coordinated patterns have been observed, such as the swarming response of neutrophils to sterile tissue injury [1]. It is not clear what factors drive these responses, but the detailed single-cell spatial-temporal location data that these microscopy technologies provide permits a simulation-based analysis approach.