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Neurobiology and Neurology

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Recent years have seen a burst of studies on the mouse eye and visual system, fueled in large part by the relatively recent ability to produce mice with precisely defined changes in gene sequence. Mouse models have contributed to a wide range of scientific breakthroughs for a number of ocular and neurological diseases and have allowed researchers to address fundamental issues that were difficult to approach with other experimental models.

Neurobiology, Ideology, and Social Change

Research shows that between birth and early adulthood the brain requires sensory stimulation to develop physically. The nature of the stimulation shapes the connections among neurons that create the neuronal networks necessary for thought and behavior. By changing the cultural environment, each generation shapes the brains of the next.

New Essays on Its Nature and the Methodology of Its Study
Edited by Murat Aydede

What does feeling a sharp pain in one's hand have in common with seeing a red apple on the table? Some say not much, apart from the fact that they are both conscious experiences. To see an object is to perceive an extramental reality—in this case, a red apple. To feel a pain, by contrast, is to undergo a conscious experience that doesn't necessarily relate the subject to an objective reality. Perceptualists, however, dispute this. They say that both experiences are forms of perception of an objective reality.

The thalamus plays a critical role in perceptual processing, but many questions remain about what thalamic activities contribute to sensory and motor functions. In this book, two pioneers in research on the thalamus examine the close two-way relationships between thalamus and cerebral cortex and look at the distinctive functions of the links between the thalamus and the rest of the brain.

Consciousness as a Biological Phenomenon

The question of consciousness is perhaps the most significant problem still unsolved by science. In Inner Presence, Antti Revonsuo proposes a novel approach to the study of consciousness that integrates findings from philosophy, psychology, and cognitive neuroscience into a coherent theoretical framework.

A Foundation for Motor Learning

Neuroscience involves the study of the nervous system, and its topics range from genetics to inferential reasoning. At its heart, however, lies a search for understanding how the environment affects the nervous system and how the nervous system, in turn, empowers us to interact with and alter our environment. This empowerment requires motor learning. The Computational Neurobiology of Reaching and Pointing addresses the neural mechanisms of one important form of motor learning.

The folk belief that the left brain hemisphere is dominant for language and the right for visuospatial functions is incomplete and even misleading. Research shows that asymmetries exist at all levels of the nervous system and apply to emotional as well as to higher cognitive processes. Going beyond the authors' previous book, Brain Asymmetry, this book reflects the most recent thinking on functional asymmetries and their structural correlates in brain anatomy.

The Collected Papers of Wilfrid Rall with Commentaries

Wilfrid Rall was a pioneer in establishing the integrative functions of neuronal dendrites that have provided a foundation for neurobiology in general and computational neuroscience in particular. This collection of fifteen previously published papers, some of them not widely available, have been carefully chosen and annotated by Rall's colleagues and other leading neuroscientists.

Allostatic Regulation in Physiology and Pathophysiology

Homeostasis, a key concept in biology, refers to the tendency toward stability in the various bodily states that make up the internal environment. Examples include temperature regulation and oxygen consumption. The body's needs, however, do not remain constant. When an organism is under stress, the central nervous system works with the endocrine system to use resources to maintain the overall viability of the organism. The process accelerates the various systems' defenses of bodily viability, but can violate short-term homeostasis.

Chemically Altered States of Consciousness

In this book J. Allan Hobson offers a new understanding of altered states of consciousness based on knowledge of how our brain chemistry is balanced when we are awake and how that balance shifts when we fall asleep and dream. He draws on recent research that enables us to explain how psychedelic drugs work to disturb that balance and how similar imbalances may cause depression and schizophrenia. He also draws on work that expands our understanding of how certain drugs can correct imbalances and restore the brain's natural equilibrium.

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