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General Interest

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An Intermediate Phenotype Approach

Although there is scientific consensus that genetic factors play a substantial role in an individual's vulnerability to drug or alcohol addiction, specific genetic variables linked to risk or resilience remain elusive. Understanding how genetic factors contribute to addiction may require focusing on intermediary mechanisms, or intermediate phenotypes, that connect genetic variation and risk for addiction. This book offers a comprehensive review of this mechanistic-centered approach and the most promising intermediate phenotypes identified in empirical research.

Evolution and Synthesis

Despite major advances in methodology and thousands of published studies every year, treatment outcomes in schizophrenia have not improved over the last fifty years. Moreover, we still lack strategies for prevention and we do not yet understand how the interaction of genetic, developmental, and environmental factors contribute to the disorder. In this book, leading researchers consider conceptual and technical obstacles to progress in understanding schizophrenia and suggest novel strategies for advancing research and treatment.

Practical Neural Zen

This is not the usual kind of self-help book. Indeed, its major premise heeds a Zen master’s advice to be less self-centered. Yes, it is "one more book of words about Zen," as the author concedes, yet this book explains meditative practices from the perspective of a "neural Zen." The latest findings in brain research inform its suggestions.

Brain-Immune Connections in Autism, Schizophrenia, and Depression

In Infectious Behavior, neurobiologist Paul Patterson examines the involvement of the immune system in autism, schizophrenia, and major depressive disorder. Although genetic approaches to these diseases have garnered the lion's share of publicity and funding, scientists are uncovering evidence of the important avenues of communication between the brain and the immune system and their involvement in mental illness. Patterson focuses on this brain-immune crosstalk, exploring the possibility that it may help us understand the causes of these common, but still mysterious, diseases.

Neuromechanics and Motor Control

This book proposes a transdisciplinary approach to investigating human motor control that synthesizes musculoskeletal biomechanics and neural control. The authors argue that this integrated approach—which uses the framework of robotics to understand sensorimotor control problems—offers a more complete and accurate description than either a purely neural computational approach or a purely biomechanical one.

Philosophy and Psychology

Reflection on the nature of hallucination has relevance for many traditional philosophical debates concerning the nature of the mind, perception, and our knowledge of the world. In recent years, neuroimaging techniques and scientific findings on the nature of hallucination, combined with interest in new philosophical theories of perception such as disjunctivism, have brought the topic of hallucination once more to the forefront of philosophical thinking.

Brain Mechanisms of Episodic Memory

Episodic memory proves essential for daily function, allowing us to remember where we parked the car, what time we walked the dog, or what a friend said earlier. In How We Remember, Michael Hasselmo draws on recent developments in neuroscience to present a new model describing the brain mechanisms for encoding and remembering such events as spatiotemporal trajectories.

Encounters with the Human Brain

Imagine the astonishment felt by neuroscientist Rodrigo Quian Quiroga when he found a fantastically precise interpretation of his research findings in a story written by the great Argentinian fabulist Jorge Luis Borges fifty years earlier. Quian Quiroga studies the workings of the brain—in particular how memory works—one of the most complex and elusive mysteries of science. He and his fellow neuroscientists have at their disposal sophisticated imaging equipment and access to information not available just twenty years ago.

Making Sense of Sound

Every time we listen—to speech, to music, to footsteps approaching or retreating—our auditory perception is the result of a long chain of diverse and intricate processes that unfold within the source of the sound itself, in the air, in our ears, and, most of all, in our brains. Hearing is an "everyday miracle" that, despite its staggering complexity, seems effortless. This book offers an integrated account of hearing in terms of the neural processes that take place in different parts of the auditory system.

Merging Both Perspectives

The study of consciousness has advanced rapidly over the last two decades. And yet there is no clear path to creating models for a direct science of human experience or for integrating its insights with those of neuroscience, psychology, and philosophy. In Inner Experience and Neuroscience, Donald Price and James Barrell show how a science of human experience can be developed through a strategy that integrates experiential paradigms with methods from the natural sciences.

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